Zinc as an inhibitor of NMDA receptor can exhibit antidepressant effect

Background : New antidepressant strategies are needed, due to unsatisfactory clinical efficacy and many side effects of commonly used drugs. Recent studies linking the pathophysiology depression with glutamatergic imbalance. There is hyperactivity main excitatory system (glutamatergic) its inhibition (GABAergic). N-methyl D-aspartate (NMDA) receptors as a part synapses potential targets for intervention. Antagonist administration systems, such zinc, can exhibit effects.
 Objective To observe effect zinc on NMDA in depressed subjects
 Methods In this paper, we provide literature review. The method achieve objective consists using exploration, which was conducted from February June 2022 by searching relevant several databases.
 Results Study trials both human animal subjects reveal that associated lower concentration zinc. Comparison between lowest intake highest had significantly incidence developing depression. Dietary deficiency induces along upregulation receptor complexes. Zinc’s might be mediated through action reducing channel-opening frequency.
 Conclusions presence may downregulate glutamate response binding receptors. Because numerous about connection depression, it seems have potency develop new antidepressants. Since capability reduce depressive symptoms, expected leading increased medication adherence, costs better outcomes.